Korea National Institute of Health - Metabolic Epigenomes
The project proposal from KNIH, consisting of Center for Genome Sciences, Macrogen, 5 chronic disease related hospital were selected for funding late 2011. The project officially started on January 1, 2012 and will run for 5~10 year. KNIH has an overall budget of 10.9 M$ for 5 years.
Overall project goal
KNIH aims to generate at least 50 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. KNIH will focus on 50 distinct types of homogenous cells of tissues related with 5 chronic diseases (Heart failure, Autoimmune Diseases, Diabetes, Obesity, Chronic Kidney Disease) from normal and disease tissue mainly obtained by tissue removal or transplantation.
The Korea reference epigenome will entail analysis of 12 'marks'. A IHEC CORE set : DNAme, H3K4me3, H3K4me1, H3K9me3, H3K27me3, H3K27ac, H3K36me3, RNA-seq, DNaseI hypersensitivity, FAIRE-Seq, miRNA, CHIA-PET).
|Disease||Tissue||Normal Cell||Disease Cell|
|Myocyte (L, R, valve)
|Obesity||FAT||Adipocyte, Preadipocyte, Macrophage, Immune cell||Adipocyte, MQ|
|Diabetes||Pancreas||....., PP, Acinus||.|
|Autoimmune Diseases : Rheumatoid Arthritis, AIDS, Asthma, HPV||Blood, Synovium||Synoviocyte, Cartilage cell, Osteoblast, Osteoclast
Blood CD4 T cell
|Synoviocyte, CD4 T cell, latent AIDS CD4 T cell Line|
|Chronic kidney Disease||Kidney||Tubule, Podocyte, Cortex, Duct, Mesangial||Tubule|
Other Non-mapping activities
- EWAS (Epigenome Wide Assaciation study)
- GWAS marker related epigenome alteration