The Common Fund’s 4D Nucleome program joins IHEC

October 06, 2017

IHEC is pleased to welcome the National Institutes of Health (NIH) and Common Fund supported program 4D Nucleome (4DN) from USA as new member to the consortium.

Launched in 2015, the 4DN program brings together researchers from various fields – several of whom have already been involved with other IHEC-related projects – to investigate the principles behind the three-dimensional organization of the nucleus in space and time (the 4th dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.

“This program builds upon the groundwork laid by IHEC and its member consortia to understand how the spatial organization of DNA in the nucleus and its interaction with nuclear structures affect genome function”, said Lisa Helbling Chadwick, Ph.D., a 4DN project team leader and a program director at the National Institute of Environmental Health Sciences (NIEHS), part of NIH.

Specifically, the 4DN consortium plans to 1) develop, benchmark, validate, standardize and apply a wide array of technologies to probe the 4D Nucleome; 2) Integrate data obtained with these technologies to generate a comprehensive view of the 4D Nucleome; and 3) Develop technologies to perturb aspects of the 4D Nucleome to assess the role of sequence elements in their formation, and to determine their biologic role in genomic processes such as transcription.

“The research teams involved in the 4DN program will bring significant new insights and perspectives to the different activities of our working groups. We are very much looking forward to this collaboration, which will further strengthen our consortium as a whole and help us advance IHEC’s major goal of producing and making available comprehensive human reference genomic and epigenomic data sets to the broad scientific community”, said Eric Marcotte, Ph.D., from the Canadian Institutes of Health Research (CIHR) and Chair of the IHEC Executive Committee.