South Korea

Korea National Institute of Health - Metabolic Epigenomes

The project proposal from KNIH, consisting of Center for Genome Sciences, Macrogen, 5 chronic disease related hospital were selected for funding late 2011. The project officially started on January 1, 2012 and will run for 5~10 year. KNIH has an overall budget of 10.9 M$ for 5 years.

Overall project goal

KNIH aims to generate at least 50 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. KNIH will focus on 50 distinct types of homogenous cells of tissues related with 5 chronic diseases (Heart failure, Autoimmune Diseases, Diabetes, Obesity, Chronic Kidney Disease) from normal and disease tissue mainly obtained by tissue removal or transplantation.

The Korea reference epigenome will entail analysis of 12  'marks'. A IHEC CORE set : DNAme, H3K4me3, H3K4me1, H3K9me3, H3K27me3, H3K27ac, H3K36me3, RNA-seq, DNaseI hypersensitivity, FAIRE-Seq, miRNA, CHIA-PET).

Cell Types

Disease Tissue Normal Cell Disease Cell
Heart Failure Heart
Blood vessel		 Myocyte (L, R, valve)
Endothelial, Fibroblast		 Myocyte(LV)
Obesity FAT Adipocyte, Preadipocyte, Macrophage, Immune cell Adipocyte, MQ
Diabetes Pancreas ....., PP, Acinus .
Autoimmune Diseases : Rheumatoid Arthritis, AIDS, Asthma, HPV Blood, Synovium Synoviocyte, Cartilage cell, Osteoblast, Osteoclast
Blood CD4 T cell		 Synoviocyte, CD4 T cell, latent AIDS CD4 T cell Line
Chronic kidney Disease Kidney Tubule, Podocyte, Cortex, Duct, Mesangial Tubule

Other Non-mapping activities