Request for Information (RFI): Challenges and Opportunities in Understanding Nuclear Organization in Space and Time (4D Nucleome)
In 2015, the NIH launched the “4D Nucleome” (4DN) Common Fund Program that aims to understand the principles underlying nuclear organization in space and time, the role nuclear organization plays in gene expression and cellular function, and how changes in nuclear organization affect normal development as well as various diseases. The initial phase of the 4DN Program includes five years of support for twenty-nine Cooperative Agreement awards and ten smaller two-year projects. 4DN data, reagents, software and tools are shared with the larger scientific community through the 4DN community portal.